TABLE 1.

Properties of the P. aeruginosa strains used in this study

StrainaPatient age (yr) when isolate was collectedGrowth rate (doubling time in min)MIC (μg/ml) of:
OfloxacinbCarbenicillinTobramycin
Parent (AMT0023-30)0.572.71 (1)641.0
AMT0023-317.781.0812832.0
AMT0023-317.774.3812832.0
AMT0023-358.080.3812832.0
96-mo isolate (AMT0023-34)8.070.8812832.0
ΔmexXY mutant (KLE2000)8.062.21 (2)1282.0
AMT0047-20.8100.02 (1)1,6000.8
AMT0047-37.3122.10.5 (1)4000.4
AMT0060-37.762.28 (14)8004.0
AMT0060-215.471.216 (16)1001.0
AMT0066-37.282.02 (0.25)2003.125
AMT0066-115.286.84 (4)800>50.0
AMT0071-23.054.32 (2)4000.8
AMT0071-39.143.31 (2)4000.8
AMT0074-19.264.516 (16)1003.125
AMT0074-319.686.816 (16)2001.56
AMT0076-310.858.92 (1)1,6006.25
AMT0076-119.656.41 (1)8000.4
AMT0101-31.039.82 (2)4001.56
AMT0101-19.6112.90.25 (0.25)2001.56
AMT0033-21.143.74 (2)8001.56
AMT0033-313.236.12 (2)800>50.0
AMT0041-15.656.44 (4)8003.125
AMT0041-312.846.716 (16)>1,600>50.0
AMT0075-17.158.21 (1)4000.8
AMT0075-423.461.92 (2)4000.8
  • a Strain pairs from individual patients are grouped by spacing. Strain pairs in boldface indicate that a hip mutant emerged during the course of infection with no increase in antimicrobial resistance.

  • b For ofloxacin, MICs for persister progeny are shown in parentheses.