TABLE 1.

A selection of genes regulated in response to a sublethal LL-37 dose

CategoryORFaDescriptionFold changeb (time [min])c
ResistanceNMB1955Cadmium resistance3.59 (30)
NMB1715mtrD2.12 (30)
NMB1763Codes for putative toxin-activating protein2.24 (30), 2.04 (60)
CapsuleNMB0068siaC2.57 (30)
NMB0067siaD2.20 (30)
NMB0082lipA1.33 (30)
OtherNMB0360Codes for ampG-related protein2.02 (30)
NMB0663nspA0.48 (60)
NMB1628Codes for putative tspB protein2.14 (30), 1.86 (60)
HypotheticalNMB1404Hypothetical3.86 (30), 2.63 (60)
NMB0660Hypothetical3.76 (30), 3.17 (60)
NMB1746Hypothetical3.28 (30), 3.37 (60)
HousekeepingNMB014030S (S10) ribosomal1.06 (30), 1.03 (60)
  • a Designations represent N. meningitidis Serogroup B genome sequence open reading frames (ORF) (27).

  • b Fold change values represent the ratios of mRNA transcript levels in LL-37-treated strain MC58 to those detected in untreated strain MC58.

  • c Values indicate whether the induced regulation occurred after 30 or 60 min of exposure to sublethal LL-37 doses.