TABLE 2.

Summary of MIC determinations and 16S rRNA gene mutations in H. pylori

Strain, transformant, or mutantMIC (μg/ml) of drug:16S rRNA gene(s)
Tetra- cyclineMetroni- dazolea
Strains
    266950.52 (1)Wild type
    10864128 (64)G360A, AGA965-967TTC
    10964128 (64)G360A, ΔG771, ΔG942, AGA965-967TTC
    1163912 (1)Wild type
    11639rdxA120.564 (64)Wild type
Transformants
    26695 (109 16S)4-162 (2)Mixed
    26695 (16S TTC)642 (2)AGA965-967TTC
    11639 (16S TTC)1282 (2)AGA965-967TTC
Mutants
    UA13740.251 (2)Insertion of cat gene into one 16S gene
    26695Tcr2NDbΔG942
    6/2Tcr2ND ΔG942
    11639Tcr8ND ΔG942
    11639rdxA12Tcr2ND ΔG942
  • a The MICs derived by the method of Jeong et al. (11) are in parentheses.

  • b ND, not done.