TABLE 3.

Virulence of P. aeruginosa efflux mutants in a rat model of acute pneumonia

StrainInoculum (106 CFU)n% MortalityaPTime to death (days)Lung wt (g)bBacterial counts in lungs (log CFU/g)
PT5 (wild type)3.022721.6 ± 0.633.98 ± 0.508.30 ± 0.54
PT625 (NalC)1.718500.192.1 ± 1.03.84 ± 0.98.53 ± 0.38
PT648 (nfxB)2.111450.151.6 ± 0.894.83 ± 1.358.85 ± 0.28
PT149 (NfxC)2.1180<0.001NRcNDdND
PT637 (NfxC, mexE)0.912420.0062.8 ± 14 ± 1.218.44 ± 0.48
  • a Statistical significance (P < 0.05) was evaluated with a Student's t test calculated versus PT5, except for PT637, which was calculated against PT149.

  • b Lung weight of uninfected rat, 1.0 ± 0.2 g.

  • c NR, not relevant.

  • d ND, not determined.