TABLE 1.

List of genes highly regulated in GBS strain 2603 V/R after exposure to pH 5.5 versus pH 7.0

TIGR locusAnnotationCommon nameFamilyFold changeaRegulation
SAG0008Transcription-repair coupling factormfdDNA metabolism13.39Up
SAG0185Hypothetical proteinCell envelope22.85Up
SAG0186Hypothetical proteinUnknown function17.97Up
SAG0290ABC transporter, substrate-binding proteinTransport and binding proteins22.98Up
SAG0291Amino acid ABC transporter, permease proteinTransport and binding proteins15.59Up
SAG0292Amino acid ABC transporter, ATP-binding proteinTransport and binding proteins11.37Up
SAG0336Helicase, putativeUnknown function10.10Up
SAG0662CylX proteinCellular processes26.00Down
SAG0663CylD proteincylDCellular processes15.78Down
SAG0664CylG proteincylGCellular processes17.93Down
SAG0665Acyl carrier protein AcpCFatty acid and phospholipid metabolism10.49Down
SAG0666CylZ proteinCellular processes28.83Down
SAG0667CylA proteincylACellular processes11.78Down
SAG0669CylE proteincylECellular processes11.03Down
SAG0670CylF proteincylFCellular processes13.95Down
SAG0671CylI proteincylICellular processes11.88Down
SAG0672CylJ proteincylJCellular processes12.75Down
SAG0673CylK proteincylKCellular processes15.20Down
SAG0723RNase IIIrncSTranscription11.48Up
SAG2063Pathogenicity proteinbibACellular processes9.1Down
SAG2125Carbamate kinasearcC-1Energy metabolism19.01Up
SAG2126Ornithine carbamoyltransferaseargF-1Amino acid biosynthesis13.73Up
  • a P < 0.0001. Except for BibA, the selected genes had an expression ratio exceeding 10-fold.