TABLE 5.

Reaction subsets calculated from extreme pathways of each subsystem of the H. pylori metabolic networka

Metabolism group and reaction subsets
Amino acid
    DHS1, AROB, AROQ, AROE, AROK, AROA, AROC
    TRPD, TRPC1, TRPC2, TRPAB
    TYRA1, TYRA2, ASPB2
    METL2, THRB, THRC
    DAPA, DAPB, DAPD, DAPC, DAPE, DAPF
    ADCSASE_r, METH
    SERA, SERC, SERB
    SPEA, SPEB
    SPED, SPEE, MTHAKN, MTHRKN, MTHIPIS, NE1PH, NE3UNK, TNSUNK
    CYSDN, CYSC, CYSH, CYSU, CYSE, CYSK
Central
    FBP, FBA_r
    GAP, PGK
    PGM, ENO
    PGL, EDD, EDA
    GLTA, ACNB, ICD
    SCOT, ATOB
Lipid and cell envelope
    ACCABCD, FABD
    FABH1, FABF
    C120SN, DGKA, LPXA, ENVA, LPXD, USHA12, LPXB, LPXK, KDTAI, KDOLIPH, ASPISO, KDSA, KDOPH, KDSB, PAPHTSE, GMHA, LPSSYN
    C141SY, C160SN, C161SY, C181SY, PLS
    PGSA2, PGPP
    GLMS, GLMM, GLMU
    MURZ, MURB, MURC, MURD, MURE, MURF, GLR, DDLA, MRAY, MURG
Nucleotide
    PYRA, PYRB, PYRC, PYRD
    PYRE, PYRF
    PURF, PURD, PURL, PURM, PURK, PURE, PURC, PURB1, PURH1, PURH2
    PURA, PURB2
    GUAB, GUAA
    NDK4, NRDAB4
    NDK6, NRDAB1
    NDK7, NRDAB3
    NDK8, TMK1
    DEOD2, DEOD8_r
Transport
    ADHE2, ETHTP_r
    PTA, ACKA
    GALU, ALGC1
    GLCTP, GLK1
    PROTPI, NATP_r
    LACTP, DLD
    BCRBTP_r, ICFA
    GLCD, GLLDHR, KATA
Vitamin and cofactor
    FOLE, DNTPH, DHPPH, FOLB, FOLK, PABB, PABC, FOLP, FOLC
    FOLD1, FOLD2
    GLTX, HEMA, HEML, HEMB, HEMC, HEMD, HEME, HEMF, HEMG, HEMH
    RIBA, RIBD1, RIBD2, PMDPHT, RIBB, RIBE, RIBC, RIBF1, RIBF2
    PANB, ILVC3, PAND, PANC, COAA, PCLIG, PCDCL, PATRAN, DPHCOAK
    IPPPISO, ISPA1, ISPA2
    NADB, NADA, NADC, NADD, NADE
    MENF, MEND1, MEND2, MENC, MENE, MENB, MENA
  • a Each set of reactions always occurs together in the same flux ratios in all type I and type II pathways in which the particular fluxes are active. Reverse enzymatic activity is indicated by the suffix “_r” at the end of a flux name.