TABLE 2.

Changes in MICs as a result of ssa inactivation

AntibioticMIC (μg/ml) for strain:
SAM1010 (Ts) [yycF1(Ts) ermB]SAM1011 (ermB)SAM1011s1 (ssa::tetK ermB)
Macrolides (14 and 16 membered) and lincosamides
    Erythromycin16>5128
    Roxithromycin32>5124
    Josamycin8>5122
    Tylosin tartrate4>5122
    Lincomycin1>5122
    Clindamycin0.25>5120.25
Representative non-MLSB-type antibiotics
    Chloramphenicol16168
    Phleomycin444
    Streptomycin222
    Vancomycin111
    Methicillin111
    Norfloxacin0.50.50.5