Table 3

Selected genes downregulated 2-fold or more under hyperosmotic stress

Functional class and proteinGeneLocus tagFold downregulation at:
15 min1.5 h3 h6 h12 h
Surface, polysaccharides, antigens
    Major antigenic peptide PEB cell binding factorpeb4cj05962.12.02.46.2
    50-kDa outer membrane protein precursoromp50cj1170c2.62.9
Transport/binding proteins
    l-Lactate permeaselctPcj0076c2.015.8
    Degenerate K+-transporting ATPase, A subunitkdpAcj06762.0
    Degenerate K+-transporting ATPase, B subunitkdpBcj06772.2
    Bifunctional adhesin/ABC transporter aspartate/glutamate binding proteinpeb1Acj0921c4.0
    Putative MFS transport proteincjaBcj0981c2.0
    Putative amino acid transporter periplasmic solute-binding proteincjaAcj0982c2.33.23.72.83.9
    Putative sodium/proline symporterputPcj1502c2.54.68.7
    Amino acid transporter (serine dehydratase)sdaCcj1625c4.93.02.55.9
Chaperones, chaperonins, heat shock, proteases
    ATP-dependent protease peptidase subunithslVcj0663c3.0
    Serine proteasehtrAcj1228c3.6
Electron transport and TCA cycle
    Molybdopterin-containing oxidoreductasecj0264c3.37.56.212.8
    Putative cytochrome c-type heme binding periplasmic proteincj0265c4.12.66.98.410.2
    Putative cytochrome c551 peroxidasecj03583.13.12.3
    Putative malate:quinone oxidoreductasemqocj0393c3.34.02.9
    Putative oxidoreductase subunitcj04144.49.1
    Putative oxidoreductase subunitcj04154.79.4
    Isocitrate dehydrogenaseicdcj05313.02.86.5
    Malate dehydrogenasemdhcj05322.12.22.25.8
    Succinyl coenzyme A synthetase beta chainsucCcj05332.310.3
    Succinyl coenzyme A synthetase alpha chainsucDcj05347.5
    2-Oxoglutarate acceptor oxidoreductase subunitoorDcj05352.26.8
    2-Oxoglutarate acceptor oxidoreductase subunitoorAcj05362.12.57.7
    2-Oxoglutarate acceptor oxidoreductase subunitoorBcj05372.42.88.5
    2-Oxoglutarate acceptor oxidoreductase subunitoorCcj05382.46.7
    Bifunctional aconitate hydratase 2,2-methylisocitrate dehydrataseacnBcj0835c2.13.04.9
    Malate oxidoreductasecj1287c2.22.02.52.3
    NADH dehydrogenase I chain NnuoNcj1566c2.43.04.4
    NADH dehydrogenase I chain MnuoMcj1567c2.33.24.3
    NADH dehydrogenase subunit LnuoLcj1568c2.32.84.6
    NADH dehydrogenase I chain KnuoKcj1569c2.12.74.0
    NADH dehydrogenase subunit JnuoJcj1570c2.53.4
    NADH dehydrogenase subunit InuoIcj1571c2.53.24.5
    NADH dehydrogenase subunit GnuoGcj1573c2.33.04.3
    Citrate synthasegltAcj1682c2.72.84.04.9
Other metabolism
    Putative phosphate acetyltransferaseptacj06883.06.9
    Acetyl coenzyme A synthetaseacscj1537c6.3
    l-Serine dehydratasesdaAcj1624c4.13.83.26.8
Amino acid biosynthesis
    Glutamine synthetaseglnAcj0699c2.52.2
    Aspartate aminotransferaseaspBcj0762c2.12.84.16.2
    Isopropylmalate isomerase small subunitleuDcj1716c3.0
    Isopropylmalate isomerase large subunitleuCcj1717c3.6
    3-Isopropylmalate dehydrogenaseleuBcj1718c4.9
    2-Isopropylmalate synthaseleuAcj1719c4.4