Table 1

Infectivity of B. burgdorferi carrying mutant NER genes in C3H/HeN mice

GenotypeStrainBlood, day 7EarOrgans, day 23
Day 14Day 21No. of sites culture positive/no. of sites tested%a
No. of sites culture positive/no. of sites tested (%)No. of sites culture positive/no. of sites tested (%)No. of sites culture positive/no. of sites tested (%)EarBladderHeartJointTotal sites
Wild type9206/6 (100)4/6 (66.7)6/6 (100)6/65/66/66/623/2495.83
uvrA5643/3 (100)0/3 (0)0/3 (50)3/33/33/33/312/12100
5653/30/33/33/33/33/33/312/12
uvrB5453/3 (100)2/3 (66.7)3/3 (100)3/31/33/33/310/1287.5
5463/32/33/33/33/32/33/311/12
uvrC5373/3 (83.3)1/3 (50)2/3 (83.3)3/33/33/33/312/1283.3
5382/32/33/32/32/32/32/38/12
uvrD5411/3 (50)0/3 (16.7)0/3 (16.7)2/32/31/32/37/1270.83
5422/31/31/33/33/31/33/310/12
  • a At day 23, 100% of the needle-inoculated mice were infected, as determined by positive spirochete cultures from at least 1 tissue specimen.