Table 2

Analysis of the CR-containing genes chtAB, cirA-chtC, and htaA in C. diphtheriae strains

StrainaOrigin/characteristicschtAB-TnbcirA-chtCchtaAdReference
NCTC13129*FSU/epidemic clone+++35
1716FSU/epidemic clone+++37
1718FSU/epidemic clone+++37
1737FSU/epidemic clone+++37
1897FSU/epidemic clone+++37
1751FSU?37
G4193FSU?37
C7*USA/lab strain38
PW8*USA/vaccine strain40
CDCE8392*CDC8
31A*Brazil/Tox+8
241*Brazil/Tox±++8
VA01*Brazil/Tox±++8
HC01*Brazil/endocarditis±++8
HC02*Brazil/endocarditis++8
HC03*Brazil/endocarditis±++8
HC04*Brazil/endocarditis±++8
INCA402*Brazil/pneumonia8
BH8*Brazil8
  • a Asterisks identify strains analyzed in the pan-genomic study described in reference 8.

  • b +, chtAB present on transposon; ±, chtAB present but not associated with a transposon; −, chtAB absent.

  • c +, cirA-chtC genes present; −, genes absent.

  • d +, htaA wild-type copy; −, htaA contains point mutations, functional status unknown (HtaA protein not detected in C7); ?, htaA status unknown.