Table 2

Impact of ΔmutM, ΔmutY, ΔmutS, ΔmutL, and ΔmutSL on spontaneous mutagenesis in 8325

StrainMutation frequency (95% CI)aFold differenceb
WT0.7 × 10−7 (0.6–1.4)1.0
ΔmutM2.2 × 10−7 (1.6–3.3)3.0**
ΔmutY7.7 × 10−7 (6.9–11.9)10.5***
ΔmutS13.4 × 10−7 (9.5–18.5)18.4***
ΔmutL17.8 × 10−7 (14.3–21.8)24.4***
ΔmutSL9.2 × 10−7 (2.3–28.8)12.5***
  • a Mutation frequency values represent the medians from 10 independent determinations of RifR CFU/viable CFU. Data in parentheses indicate the 95% confidence interval (CI).

  • b Fold difference values were calculated with respect to the median for the (WT) 8325 strain. **, P ≤ 0.01; ***, P ≤ 0.001 (for comparisons to the WT based on the Mann-Whitney test).