Table 3

Impact of ΔmutM, ΔmutY, ΔmutS, ΔmutL, and ΔmutSL on spontaneous mutagenesis in HG003

StrainMutation frequency (95% CI)aFold differenceb
WT0.2 × 10−7 (0.1–0.3)1.00
ΔmutM0.4 × 10−7 (0.2–0.7)2.4**
ΔmutY1.7 × 10−7 (0.8–5.1)8.8***
ΔmutS5.6 × 10−7 (4.4–8.7)28.7***
ΔmutL6.5 × 10−7 (14.3–21.8)31.5***
ΔmutSL9.15 × 10−7 (2.3–28.8)34.2***
  • a Mutation frequency values represent the medians from 10 independent determinations of RifR CFU/viable CFU. Data in parentheses indicate the 95% confidence interval (CI).

  • b Fold difference values were calculated with respect to the median for the (WT) SAHG003 strain. **, P ≤ 0.01; ***, P ≤ 0.001 (for comparisons to the WT based on the Mann-Whitney test).