Table 4

Impact of rsbU and tcaR mutation on spontaneous mutagenesis in 8325 lineage

StrainrsbUatcaRaMutation frequency (95% CI)bFold differencec
83257.3 × 10−8 (5.9–13.8)1.00
HG001+2.8 × 10−8 (2.1–3.5)0.38**
HG002+7.6 × 10−8 (4.5–16.9)1.04
HG003++1.9 × 10−8 (1.3–3.0)0.26***
  • a Status of rsbU and tcaR: +; functional; −, dysfunctional.

  • b Mutation frequency values represent the medians from 10 independent determinations of RifR CFU/viable CFU. Data in parentheses indicate the 95% confidence interval (CI).

  • c Fold difference values were calculated with respect to the median for the 8325 strain. **, P ≤ 0.01; ***, P ≤ 0.001 (for comparisons to strain 8325 based on the Mann-Whitney test).