Table 1

Top-quality POG signatures for virus taxaa

Virus cladeNo. of genomesSignature gene(s)
POG no.Function(s)
Order Caudovirales, family Siphoviridae
    T1-like viruses52763, 2765, 2766, 2771, 2773, 2778, 2780, 2802Holin, transcriptional regulator, hypothetical proteins
    L5-like viruses31603, 1605Hypothetical proteins
    ϕC31-like viruses33419, 3420, 3421, 3422Major capsid, hypothetical proteins (possible RNA polymerase sigma factor)
Order Caudovirales, family Myoviridae
    CBA120-like viruses43145Calcium-binding hemolysin protein
    Hp1-like virus62211, 2212, 2213, 2216Tail sheath and tail completion proteins, hypothetical proteins
    Bcep781-like virus53660, 3661, 3664Hypothetical proteins (possible terminase small subunit)
    FelixO1-like virus31350, 1425Structural protein, hypothetical protein
    ϕCD119-like virus34377, 4378, 4382, 4383Resolvase/integrase, hypothetical proteins
    Spounavirinae120072Tail protein
    ϕKZ-like viruses33252, 3254, 3245DNA-directed RNA polymerase beta subunit, structural protein, hypothetical protein
Order Caudovirales, family Podoviridae
    T7-like viruses290036, 0041Internal virion protein, DNA packaging/maturation protein
    SP6-like viruses61055, 1056, 1057, 1058, 1061, 1064, 1065, 1066DNA-endonuclease-like protein, internal virion protein, hypothetical proteins (possible tail assembly)
    AHJD-like viruses43732Hypothetical protein (CHAP domain)
    ϕ29-like viruses50875, 0876, 0878, 0879, 0885Terminal protein, transcriptional regulator, dsDNA-binding protein, scaffolding protein, early protein
    N4-like viruses82377, 2380, 2383, 2384, 2387, 2389, 2390Major coat protein, ssDNA-binding protein, hypothetical proteins (several possibly structural)
    Fuselloviridae63362Hypothetical protein
    Fusellovirus63354, 3362Hypothetical proteins
    Lipothrixviridae83538Hypothetical protein
    Betalipothrixvirus63504, 3508, 3508RHH transcriptional regulator, structural protein, hypothetical protein (possibly structural)
    ssRNA viruses/Leviviridae100166, 0167Maturation protein, RNA replicase beta
    dsRNA viruses/Cystoviridae54542RNA-dependent RNA polymerase
  • a The table includes virus-specific signature genes present in a single copy in all genomes of the specified clade but not outside of it, in the POGs tests against virus proteins in complete genomes, and against all known virus proteins in the nr database (VQ, 1.0; recall, 100%; precision, 100%). For each virus clade, the order (when assigned) is given, along with the number of genomes in that clade, the number of signatures that meet these criteria, and the (predicted) function of the signature genes.