TABLE 6

Site-directed mutations in Rota

MutationLocationPredicted contact
R91AWingSpecific DNA
K64A-R70AHTH-RHSpecific DNA
Y66AHTH-RHSpecific DNA
K67AHTH-RHSpecific DNA
L54A/K55AHTH-α3Nonspecific DNA
T71A/N74AHTH-RHNonspecific DNA
N74AHTH-RHNonspecific DNA
L41A/L44ACore-α2Nonspecific DNA
S36A/E38A/E39ACore-α2Nonspecific DNA
E39ACore-α2Nonspecific DNA
F10A/L13A/Q14A/T17ACore-α1Protein partners
F10ACore-α1Protein partners
L13ACore-α1Protein partners
Q14ACore-α1Protein partners
Q14ECore-α1Protein partners
T17ACore-α1Protein partners
Q48ACore-α2Protein partners
  • a The location of each mutation within the protein and the predicted contact interrupted by each mutant are indicated.