TABLE 1.

Quorum-activated genes

Gene no.aDescriptionbMaximum changec
lasI rhlI mutantWild type vs lasR rhlR mutant
3OC12-HSLC4-HSL + 3OC12-HSL
PA0007Hypothetical protein4.45.7 (2.0)14 (1.4)
PA0026Hypothetical proteind4.44.4 (1.4)5.9 (0.2)
PA0027Hypothetical protein3.84.9 (0.8)5.7 (0.2)
PA0028Hypothetical protein5.87.5 (1.4)8.2 (1.4)
PA0050Hypothetical protein2.82.5 (2.0)3.0 (1.4)
PA0052Hypothetical proteind4.78.3 (1.4)22 (2.0)
PA0059 osmC, osmotically inducible protein OsmC2.56.7 (2.0)8.9 (2.0)
PA0105 coxB, cytochrome c oxidase subunit II3.44.0 (2.0)2.6 (2.0)
PA0106 coxA, cytochrome c oxidase subunit I4.24.8 (1.4)3.3 (1.4)
PA0107Conserved hypothetical protein4.14.8 (2.0)4.9 (2.0)
PA0108 coIII, cytochrome c oxidase subunit III3.03.6 (2.0)2.8 (2.0)
PA0109 qsc115, hypothetical protein2.13.5 (1.4)4.1 (1.4)
PA0122Conserved hypothetical proteine1336 (1.4)51 (1.4)
PA0132Beta-alanine-pyruvate transaminase1.63.1 (1.4)4.1 (2.0)
PA0143Probable nucleoside hydrolase4.74.7 (0.4)5.4 (0.1)
PA0144Hypothetical protein1.519 (2.0)28 (2.0)
PA0158Probable RND efflux transporter2.62.6 (2.0)2.6 (2.0)
PA0175Probable chemotaxis protein methyltransferase2.02.6 (3.0)4.6 (1.4)
PA0176Probable chemotaxis transducer2.12.6 (3.0)3.9 (1.4)
PA0179Probable two-component response regulator2.72.8 (1.4)3.7 (1.4)
PA0198 exbBI, transport protein ExbB7.310 (4.0)3.7 (4.0)
PA0263 hcpC, secreted protein Hcp1.78.9 (1.4)9.4 (1.4)
PA0355 pfpI, protease PfpI2.34.8 (2.0)8.1 (2.0)
PA0364Probable oxidoreductase2.93.1 (2.0)3.0 (2.0)
PA0365Hypothetical protein2.02.5 (2.0)2.7 (2.0)
PA0366Probable aldehyde dehydrogenase2.42.8 (2.0)2.5 (3.0)
PA0534Conserved hypothetical protein1.52.9 (4.0)9.8 (2.0)
PA0567Conserved hypothetical protein6.915 (2.0)11 (2.0)
PA0572Hypothetical protein1922 (0.4)19 (0.05)
PA0586Conserved hypothetical protein2.12.6 (1.4)4.6 (1.4)
PA0852 qsc129, cpbD, chitin-binding protein CbpD precursord1143 (0.4)94 (0.1)
PA0855 qsc116, hypothetical protein2.42.5 (0.8)3.0 (0.8)
PA0996Probable coenzyme A ligasee22090 (0.8)42 (0.2)
PA0997Hypothetical protein11096 (0.8)200 (0.05)
PA0998Hypothetical protein6840 (0.4)200 (0.2)
PA0999 fabHI, 3-oxoacyl-(acyl carrier protein) synthase III3725 (0.8)45 (0.2)
PA1000Hypothetical protein2212 (0.8)44 (0.2)
PA1001 phnA, anthranilate synthase component I3923 (0.8)290 (0.2)
PA1002 phnB, anthranilate synthase component II1713 (1.4)28 (0.8)
PA1003Probable transcriptional regulator8.16.6 (0.2)78 (0.05)
PA1130Hypothetical protein2.49.4 (1.4)16 (1.4)
PA1131Probable MFS transporterd1.75.0 (2.0)7.9 (1.4)
PA1173 napB, cytochrome c-type protein NapB precursor2.32.8 (2.0)4.1 (1.4)
PA1175 napD, NapD protein of periplasmic nitrate reductase2.62.4 (2.0)3.8 (1.4)
PA1176 napF, ferredoxin protein NapF2.52.5 (2.0)5.8 (1.4)
PA1177 napE, periplasmic nitrate reductase protein NapE2.93.6 (1.4)3.6 (1.4)
PA1215Hypothetical proteinNC18 (1.4)55 (1.4)
PA1216Hypothetical protein4.715 (0.8)120 (0.8)
PA1217Probable 2-isopropylmalate synthase2.941 (1.4)380 (1.4)
PA1218Hypothetical proteinNC6.9 (1.4)160 (1.4)
PA1221Hypothetical proteineNC3.1 (3.0)11 (1.4)
PA1245Hypothetical proteine8.610 (0.8)11 (0.2)
PA1246 aprD, alkaline protease secretion protein AprD8.69.8 (1.4)6.6 (0.8)
PA1247 aprE, alkaline protease secretion protein AprE6.26.4 (1.4)9.1 (1.4)
PA1248 aprF, alkaline protease secretion protein AprF7.27.6 (1.4)5.2 (1.4)
PA1249 aprA, alkaline metalloproteinase precursor2527 (1.4)22 (1.4)
PA1250 aprI, alkaline proteinase inhibitor AprId2020 (0.2)24 (0.05)
PA1289Hypothetical protein2.95.7 (1.4)2.6 (1.4)
PA1317 cyoA, cytochrome o ubiquinol oxidase subunit II2.54.7 (4.0)15 (2.0)
PA1318 cyoB, cytochrome o ubiquinol oxidase subunit INC3.9 (4.0)16 (2.0)
PA1319 cyoC, cytochrome o ubiquinol oxidase subunit III2.04.8 (4.0)7.9 (3.0)
PA1320 cyoD, cytochrome o ubiquinol oxidase subunit IV4271 (4.0)9.1 (3.0)
PA1323Hypothetical protein2.86.1 (2.0)9.6 (2.0)
PA1324Hypothetical protein2.45.3 (2.0)8.5 (2.0)
PA1404Hypothetical protein2.02.7 (2.0)3.8 (2.0)
PA1431 rsaL , regulatory protein RsaLd350340 (0.2)39 (0.8)
PA1432 lasI , autoinducer synthesis protein LasIdNCfNCf7.7 (0.8)
PA1656Hypothetical proteina2.43.7 (1.4)5.7 (0.8)
PA1657Conserved hypothetical protein5.915 (0.4)24 (0.8)
PA1658Conserved hypothetical protein3.99.3 (0.8)17 (0.8)
PA1659Hypothetical protein4.18.5 (0.8)17 (0.8)
PA1660Hypothetical protein2.67.9 (0.8)16 (0.8)
PA1661Hypothetical protein2.34.4 (1.4)4.4 (0.8)
PA1662Probable ClpA/B-type protease2.96.6 (1.4)7.7 (0.8)
PA1663Probable transcriptional regulator2.54.5 (0.8)9.1 (0.8)
PA1664Hypothetical protein5.916 (0.4)22 (0.8)
PA1665Hypothetical protein2155 (1.4)28 (0.8)
PA1666Hypothetical protein2.912 (0.8)38 (0.8)
PA1667Hypothetical protein3.17.6 (0.8)12 (0.8)
PA1668Hypothetical protein2.84.6 (0.8)6.3 (0.8)
PA1669Hypothetical protein2.23.8 (1.4)17 (0.8)
PA1670 stp1, serine/threonine phosphoprotein phosphatase Stp1NC2.8 (1.4)3.6 (0.8)
PA1745Hypothetical protein2.12.6 (2.0)2.8 (1.4)
PA1784Hypothetical proteine1415 (1.4)18 (1.4)
PA1869 qsc117, probable acyl carrier proteine7.841 (0.2)340 (0.2)
PA1870Hypothetical proteinNC3.2 (2.0)6.3 (2.0)
PA1871 lasA , LasA protease precursord4888 (0.8)130 (1.4)
PA1881Hypothetical protein2.42.6 (2.0)2.8 (1.4)
PA1888Hypothetical protein2.72.3 (2.0)4.3 (1.4)
PA1891Hypothetical protein3.34.3 (2.0)6.5 (0.8)
PA1893Hypothetical protein1613 (0.4)2.7 (2.0)
PA1894 qsc101, hypothetical protein5959 (0.8)5.0 (1.4)
PA1895Hypothetical protein3631 (0.8)4.2 (1.4)
PA1896Hypothetical protein4149 (1.4)3.1 (1.4)
PA1897 qsc102, hypothetical proteine130130 (0.4)8.5 (0.8)
PA1914Conserved hypothetical protein42190 (2.0)700 (2.0)
PA1921Hypothetical proteinNC14 (2.0)13 (2.0)
PA1930Probable chemotaxis transducer2.22.9 (2.0)3.8 (1.4)
PA1939Hypothetical protein2.63.2 (1.4)2.9 (2.0)
PA2030Hypothetical protein3.34.2 (2.0)14 (2.0)
PA2031Hypothetical protein4.56.5 (0.4)12 (1.4)
PA2066Hypothetical protein1.93.7 (2.0)12 (1.4)
PA2067Probable hydrolase1.85.0 (2.0)19 (1.4)
PA2068Probable MFS transporterNC16 (1.4)150 (1.4)
PA2069Probable carbamoyl transferaseeNC45 (1.4)110 (0.2)
PA2076Probable transcriptional regulatord3.74.3 (0.2)4.3 (0.2)
PA2080Hypothetical protein3.54.0 (0.2)4.0 (0.2)
PA2081Hypothetical protein3.34.3 (0.2)3.6 (0.2)
PA2134Hypothetical protein3.15.4 (3.0)7.9 (2.0)
PA2142Probable short-chain dehydrogenaseNC3.6 (3.0)19 (2.0)
PA2143Hypothetical protein2139 (2.0)51 (2.0)
PA2144 glgP, glycogen phosphorylase2.54.7 (3.0)15 (2.0)
PA2146Conserved hypothetical protein2.74.8 (3.0)11 (2.0)
PA2147 katE, catalase HPII3.57.1 (2.0)35 (2.0)
PA2148Conserved hypothetical proteinNC3.1 (2.0)3.4 (2.0)
PA2151Conserved hypothetical protein2.638 (2.0)34 (2.0)
PA2152Probable trehalose synthase2.15.3 (2.0)6.1 (2.0)
PA2153 glgB, 1,4-alpha-glucan branching enzyme2.15.6 (2.0)16 (2.0)
PA2156Conserved hypothetical protein2.34.8 (3.0)17 (2.0)
PA2157Hypothetical protein2.12.8 (3.0)2.9 (3.0)
PA2158Probable alcohol dehydrogenase (Zn dependent)6.715 (2.0)26 (2.0)
PA2159Conserved hypothetical protein4.15.9 (2.0)10 (2.0)
PA2160Probable glycosyl hydrolased2.34.4 (3.0)5.8 (2.0)
PA2161Hypothetical proteind4.46.3 (2.0)10 (2.0)
PA2163Hypothetical protein2.26.9 (2.0)31 (2.0)
PA2164Probable glycosyl hydrolase2.54.7 (2.0)6.5 (2.0)
PA2165Probable glycogen synthase3.25.7 (2.0)6.3 (2.0)
PA2166Hypothetical protein3.19.1 (2.0)17 (2.0)
PA2167Hypothetical protein2.32.6 (2.0)4.7 (2.0)
PA2169Hypothetical protein2.85.7 (2.0)5.1 (2.0)
PA2170Hypothetical protein3.66.9 (2.0)13 (2.0)
PA2171Hypothetical protein5.29.1 (2.0)22 (2.0)
PA2172Hypothetical protein3.87.7 (2.0)12 (2.0)
PA2173Hypothetical protein3.56.5 (2.0)17 (2.0)
PA2176Hypothetical protein1.45.3 (2.0)27 (2.0)
PA2180Hypothetical protein1.92.6 (3.0)2.7 (3.0)
PA2190Conserved hypothetical protein3.44.5 (2.0)7.5 (2.0)
PA2192Conserved hypothetical proteinNC10 (2.0)8.4 (2.0)
PA2193 hcnA, hydrogen cyanide synthase HcnAe140190 (0.2)88 (0.2)
PA2194 qsc128, hcnB, hydrogen cyanide synthase HcnB3751 (0.2)59 (0.8)
PA2195 hcnC, hydrogen cyanide synthase HcnC1630 (0.4)46 (0.8)
PA2274Hypothetical proteinNC3.4 (3.0)11 (2.0)
PA2300 chiC, chitinasee1.714 (1.4)100 (1.4)
PA2302 qsc100, probable nonribosomal peptide synthetase5.27.9 (0.8)130 (1.4)
PA2303 qsc107, hypothetical protein2528 (0.4)130 (0.2)
PA2304Hypothetical protein8.412 (0.8)29 (0.8)
PA2305Probable nonribosomal peptide synthetase5251 (0.2)70 (0.2)
PA2327Probable permease of ABC transporter5.98.9 (4.0)6.9 (4.0)
PA2328Hypothetical protein6.89.1 (2.0)7.5 (3.0)
PA2329Probable component of ABC transporter7.89.9 (1.4)18 (3.0)
PA2330Hypothetical protein7.911 (0.8)15 (2.0)
PA2331Hypothetical protein8.319 (1.4)20 (1.4)
PA2345Conserved hypothetical proteine2.23.2 (2.0)2.6 (2.0)
PA2365Conserved hypothetical protein4.75.4 (1.4)5.9 (1.4)
PA2366Conserved hypothetical protein4.35.2 (1.4)6.9 (1.4)
PA2367Hypothetical protein4.85.1 (1.4)6.4 (1.4)
PA2368Hypothetical protein3.53.4 (1.4)7.5 (1.4)
PA2370Hypothetical protein2.93.6 (3.0)3.5 (1.4)
PA2371Probable ClpA/B-type protease2.42.6 (3.0)5.0 (1.4)
PA2372Hypothetical protein3.22.7 (2.0)3.7 (1.4)
PA2414 l-Sorbosone dehydrogenase3.14.9 (2.0)21 (0.2)
PA2415Hypothetical protein3.55.6 (2.0)14 (2.0)
PA2423Hypothetical protein1111 (0.4)13 (0.2)
PA2433Hypothetical protein2.85.9 (2.0)11 (2.0)
PA2442 gcvT2, glycine cleavage system protein T22.02.6 (3.0)3.1 (3.0)
PA2444 glyA2, serine hydroxymethyltransferase9.112 (3.0)10 (3.0)
PA2445 gcvP2, glycine cleavage system protein P26.67.5 (4.0)11 (3.0)
PA2446 gcvH2, glycine cleavage system protein H21217 (4.0)18 (3.0)
PA2448Hypothetical proteinNC4.1 (3.0)12 (1.4)
PA2512 antA, anthranilate dioxygenase large subunit−60043 (2.0)27 (3.0)
PA2513 antB, anthranilate dioxygenase small subunit−9614 (2.0)13 (3.0)
PA2514 antC, anthranilate dioxygenase reductase−679.3 (2.0)3.8 (4.0)
PA2564Hypothetical protein2.97.8 (2.0)21 (1.4)
PA2565Hypothetical protein3.16.6 (2.0)14 (2.0)
PA2566Conserved hypothetical proteine6.513 (2.0)21 (1.4)
PA2570 pa1L, PA-1 galactophilic lectindNC26 (1.4)200 (1.4)
PA2572Probable two-component response regulator2.32.8 (1.4)3.3 (1.4)
PA2573Probable chemotaxis transducer2.34.1 (1.4)3.9 (1.4)
PA2587 qsc105, probable FAD-dependent monooxygenase1212 (0.2)15 (0.1)
PA2588Probable transcriptional regulator1522 (0.2)46 (0.8)
PA2591Probable transcriptional regulatore2125 (0.2)42 (0.2)
PA2592 qsc104, probable spermidine-putrescine-binding proteine5.68.7 (0.4)15 (0.8)
PA2593Hypothetical proteinNC4.6 (2.0)29 (0.8)
PA2717 cpo, chloroperoxidase precursor2.42.6 (2.0)3.4 (1.4)
PA2747Hypothetical protein3.67.2 (2.0)11 (2.0)
PA2927Hypothetical protein2.63.4 (2.0)14 (1.4)
PA2939Probable aminopeptidase3842 (1.4)27 (1.4)
PA3022Hypothetical protein3.54.7 (2.0)4.3 (2.0)
PA3032 qsc135, cytochrome c2.33.3 (2.0)9.3 (2.0)
PA3104 xcpP, secretion protein XcpP3.13.2 (2.0)4.7 (1.4)
PA31812-Keto-3-deoxy-6-phosphogluconate aldolase1.62.9 (3.0)3.2 (3.0)
PA3182Conserved hypothetical protein1.73.2 (3.0)5.0 (3.0)
PA3183 zwf, glucose-6-phosphate 1-dehydrogenase2.03.7 (3.0)4.0 (3.0)
PA3188Probable permease of ABC sugar transporter2.94.2 (2.0)6.8 (3.0)
PA3189Probable permease of ABC sugar transporter2.02.5 (3.0)3.0 (3.0)
PA3190Probable component of ABC sugar transporter2.73.4 (2.0)4.1 (3.0)
PA3194 edd, phosphogluconate dehydratase2.03.2 (3.0)2.9 (3.0)
PA3195 gapA, glyceraldehyde-3-phosphate dehydrogenase3.15.0 (3.0)5.4 (3.0)
PA3274Hypothetical proteind1.94.3 (2.0)10 (2.0)
PA3311Conserved hypothetical protein3.63.6 (2.0)6.0 (1.4)
PA3326Probable Clp family ATP-dependent proteasee6.620 (0.4)19 (0.8)
PA3327 qsc126, probable nonribosomal peptide synthetaseeNC6.8 (0.8)20 (0.8)
PA3328 qsc125, probable FAD-dependent monooxygenaseNC17 (0.4)47 (0.8)
PA3329 qsc124, hypothetical proteinNC250 (0.4)310 (0.8)
PA3330 qsc123, probable short-chain dehydrogenaseNC120 (0.4)320 (0.8)
PA3331 qsc122, cytochrome P4503.539 (0.4)62 (0.8)
PA3332Conserved hypothetical protein2.335 (0.8)41 (1.4)
PA3333 qsc121, fabH2, 3-oxoacyl-(acyl carrier protein) synthase IIINC32 (0.4)64 (0.8)
PA3334Probable acyl carrier protein1.849 (0.4)69 (0.8)
PA3335Hypothetical proteinNC9.6 (0.4)29 (1.4)
PA3336 qsc120, probable MFS transporterNC22 (1.4)24 (0.8)
PA3346Probable two-component response regulator2.72.8 (2.0)4.7 (2.0)
PA3347Hypothetical proteinc2.32.8 (2.0)4.3 (1.4)
PA3361Hypothetical protein1013 (1.4)68 (1.4)
PA3369Hypothetical protein1.93.3 (2.0)4.8 (2.0)
PA3370Hypothetical protein1.73.5 (2.0)5.6 (2.0)
PA3371Hypothetical protein1.73.6 (2.0)6.0 (2.0)
PA3416Probable pyruvate dehydrogenase component2.53.2 (2.0)4.1 (1.4)
PA3418 ldh, leucine dehydrogenase2.63.7 (1.4)5.0 (1.4)
PA3476 qsc118, rhlI, autoinducer synthesis protein RhlIeNCfNCf34 (0.05)
PA3477 rhlR, transcriptional regulator RhlR8.59.6 (0.4)130 (0.05)
PA3478 qsc119, rhlB, rhamnosyltransferase chain B5.389 (0.8)120 (1.4)
PA3479 qsc119, rhlA, rhamnosyltransferase chain Ae10120 (0.8)200 (0.8)
PA3520Hypothetical proteind2.213 (1.4)32 (1.4)
PA3535Probable serine protease7.58.1 (0.4)5.9 (0.8)
PA3676Probable RND efflux transporter3.91.9 (2.0)5.8 (1.4)
PA3677Probable RND efflux protein precursor3.63.8 (2.0)8.3 (1.4)
PA3678Probable transcriptional regulator2.91.6 (2.0)3.5 (1.4)
PA3688Hypothetical protein3.05.4 (0.2)3.5 (1.4)
PA3691Hypothetical protein2.44.5 (2.0)6.3 (2.0)
PA3692Probable outer membrane protein3.05.8 (2.0)6.9 (2.0)
PA3724 lasB, elastase LasBe110180 (0.8)240 (0.8)
PA3734Hypothetical proteinNC4.1 (3.0)16 (2.0)
PA3888Probable permease of ABC transporterNC3.2 (2.0)3.9 (2.0)
PA3890Probable permease of ABC transporter1.84.1 (2.0)4.7 (2.0)
PA3891Probable component of ABC transporter2.15.0 (2.0)8.2 (2.0)
PA3904Hypothetical protein4942 (0.2)46 (0.05)
PA3905Hypothetical protein3759 (0.2)87 (0.05)
PA3906Hypothetical protein140130 (0.2)71 (0.05)
PA3907 qsc103, hypothetical protein2019 (0.2)58 (0.05)
PA3908Hypothetical protein1011 (0.2)55 (0.05)
PA3986Hypothetical protein2.73.3 (1.4)2.8 (2.0)
PA4078 qsc134, probable nonribosomal peptide synthetased3.24.6 (2.0)20 (2.0)
PA4117Probable bacteriophytochrome5.35.6 (1.4)4.3 (1.4)
PA4129Hypothetical protein2531 (0.8)15 (0.8)
PA4130Probable sulfite or nitrite reductase2327 (0.8)1 (0.8)
PA4131Probable iron-sulfur protein2430 (0.8)21 (0.8)
PA4132Conserved hypothetical protein1415 (0.8)6.4 (0.8)
PA4133Cytochrome c oxidase subunit (cbb3 type)100100 (0.8)37 (0.8)
PA4134Hypothetical protein4347 (0.8)21 (0.8)
PA4139Hypothetical protein3.12.9 (2.0)3.9 (2.0)
PA4141Hypothetical protein2.626 (0.4)73 (1.4)
PA4142Probable secretion proteinNC5.2 (2.0)16 (1.4)
PA4171Probable protease3.54.6 (2.0)5.1 (2.0)
PA4172Probable nuclease2.03.4 (2.0)14 (2.0)
PA4175Probable endoproteinase Arg-C precursor1115 (2.0)23 (1.4)
PA4190Probable FAD-dependent monooxygenase3.02.5 (1.4)4.0 (0.2)
PA4205Hypothetical protein1.98.7 (3.0)56 (2.0)
PA4206Probable RND efflux protein precursor1.76.3 (3.0)30 (2.0)
PA4207 qsc133, probable RND efflux transporterNC2.5 (3.0)17 (2.0)
PA4208Probable outer membrane efflux protein1.63.1 (3.0)19 (2.0)
PA4209Probable O-methyltransferasee4.611 (1.4)27 (1.4)
PA4210Probable phenazine biosynthesis proteine, gNC59 (1.4)71 (1.4)
PA4211Probable phenazine biosynthesis proteind1069 (0.8)220 (0.8)
PA4212 qsc131, phenazine biosynthesis protein PhzCd2.215 (1.4)77 (1.4)
PA4213Phenazine biosynthesis protein PhzD3.736 (1.4)210 (1.4)
PA4214Phenazine biosynthesis protein PhzE2.518 (1.4)59 (1.4)
PA4215Probable phenazine biosynthesis protein3.124 (1.4)110 (1.4)
PA4216Probable pyridoxamine 5-phosphate oxidase3.021 (1.4)56 (1.4)
PA4217 qsc132, probable FAD-dependent monooxygenase4.428 (1.4)41 (1.4)
PA4296Probable two-component response regulator2.43.6 (1.4)5.6 (1.4)
PA4297Hypothetical protein2.43.3 (2.0)12 (2.0)
PA4298Hypothetical protein2.34.7 (2.0)8.7 (2.0)
PA4299Hypothetical protein2.13.6 (2.0)7.0 (2.0)
PA4300Hypothetical protein2.03.5 (2.0)7.8 (2.0)
PA4302Probable type II secretion system protein3.26.1 (2.0)7.4 (2.0)
PA4304Probable type II secretion system protein2.23.1 (2.0)6.1 (2.0)
PA4305Hypothetical protein2.12.7 (2.0)5.9 (2.0)
PA4306Hypothetical protein1016 (1.4)38 (1.4)
PA4311Conserved hypothetical protein2.53.2 (2.0)2.6 (2.0)
PA4384Hypothetical proteinNC2.7 (3.0)4.0 (3.0)
PA4498Probable metallopeptidase1.64.5 (3.0)9.1 (3.0)
PA4590 pra, protein activator9.314 (1.4)13 (0.8)
PA4648Hypothetical protein3.47.7 (2.0)17 (1.4)
PA4649Hypothetical proteinNC3.2 (2.0)7.4 (1.4)
PA4650Hypothetical proteinNC3.3 (2.0)8.8 (2.0)
PA4651Probable pilus assembly chaperonedNC4.6 (2.0)15 (2.0)
PA4652Hypothetical protein6.013 (2.0)9.6 (2.0)
PA4677Hypothetical protein1613 (0.2)36 (0.1)
PA4703Hypothetical protein3.14.3 (2.0)3.5 (1.4)
PA4738Conserved hypothetical protein3.89.1 (2.0)11 (2.0)
PA4739Conserved hypothetical protein4.29.4 (2.0)14 (2.0)
PA4778Probable transcriptional regulator5.44.9 (0.4)8.6 (0.1)
PA4869 qsc106, hypothetical proteind5.05.7 (0.4)3.8 (0.1)
PA4876 osmE, osmotically inducible lipoprotein OsmE2.33.6 (2.0)4.9 (2.0)
PA4880Probable bacterioferritin2.24.6 (2.0)5.8 (2.0)
PA4916Hypothetical protein1.54.3 (4.0)6.1 (2.0)
PA4917Hypothetical proteind1.45.8 (2.0)7.7 (2.0)
PA4925Conserved hypothetical protein3.83.7 (2.0)5.7 (1.4)
PA5027Hypothetical proteine1.52.8 (2.0)3.2 (3.0)
PA5058 phaC2, poly(3-hydroxyalkanoic acid) synthase 2e4.54.7 (1.4)9.2 (1.4)
PA5059Probable transcriptional regulator4.45.9 (2.0)9.3 (1.4)
PA5061Conserved hypothetical protein1.72.5 (4.0)2.6 (4.0)
PA5161 rmlB, dTDP-d-glucose 4,6-dehydrataseNC2.9 (4.0)5.9 (3.0)
PA5162 rmlD, dTDP-4-dehydrorhamnose reductaseNC2.5 (4.0)4.9 (3.0)
PA5164 rmlC, dTDP-4-dehydrorhamnose 3,5-epimeraseNC2.6 (3.0)5.6 (2.0)
PA5220 qsc138, hypothetical protein2.818 (0.8)26 (1.4)
PA5352Conserved hypothetical protein2.02.8 (1.4)2.9 (1.4)
PA5353 glcF, glycolate oxidase subunit GlcF1.93.4 (1.4)3.5 (1.4)
PA5354 glcE, glycolate oxidase subunit GlcE2.02.6 (1.4)3.2 (1.4)
PA5355 glcD, glycolate oxidase subunit GlcD2.13.6 (1.4)3.8 (1.4)
PA5356 qsc130, glcC, transcriptional regulator GlcC2.44.1 (1.4)2.8 (1.4)
PA5415 glyA1, serine hydroxymethyltransferase2.62.8 (3.0)5.0 (3.0)
PA5481Hypothetical protein4.111 (2.0)15 (1.4)
PA5482Hypothetical protein5.415 (2.0)18 (1.4)
  • a Gene number from the Pseudomonas genome project (http://www.pseudomonas.com).

  • b Boldface type indicates genes or gene products previously reported to be controlled by quorum sensing. RND, resistance-nodulation-cell division; FAD, flavin adenine dinucleotide.

  • c Maximum changes (fold) in gene expression (rounded to two significant figures) in the signal generation mutant in the presence of the signal(s) indicated compared with the absence of signal and in the wild-type P. aeruginosa strain compared with the receptor mutant. The values in parentheses are the OD600 at which the earliest change of ≥2.5-fold was observed (for the signal generation mutant both time courses were considered). NC, no change.

  • d There is a las-rhl box-like sequence with an HI of ≥10 and <13.

  • e There is a las-rhl box-like sequence with an HI of <10.

  • f The transcript levels for lasI and rhlI were close to the background level in the signal generation mutant due to the disruption of both loci by insertional mutagenesis.

  • g The GeneChip probes for PA4210 to PA4216 are identical to those for PA1899 to PA1905. Although the sequences for the genes in these two clusters are almost identical, the region upstream of PA4210 contains a las-rhl box-like sequence, but the region upstream of PA1899 does not.