antibiotics
MinireviewThe Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological FunctionsBacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs from the bacterial cell, which significantly contributes to multidrug resistance. Intriguingly, most drug efflux pumps are chromosomally encoded components of the intrinsic antibiotic resistome. In addition, in terms of xenobiotic detoxification, bacterial...
Research ArticlePseudomonas aeruginosa PA14 Enhances the Efficacy of Norfloxacin against Staphylococcus aureus Newman BiofilmsPseudomonas aeruginosa and Staphylococcus aureus are frequently coisolated from multiple infection sites, including the lungs of individuals with cystic fibrosis (CF) and nonhealing diabetic foot ulcers. Coinfection with P. aeruginosa...
Minireview“It Takes a Village”: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial BiofilmsChronic infections are frequently caused by polymicrobial biofilms. Importantly, these infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to antimicrobial therapy. Emerging evidence suggests that polymicrobial interactions can lead to dramatic and unexpected changes in the ability of antibiotics to eradicate biofilms and often result in decreased antimicrobial efficacy in vitro....
Research ArticlePQS Produced by the Pseudomonas aeruginosa Stress Response Repels Swarms Away from Bacteriophage and AntibioticsWe uncover a phage- and antibiotic-induced stress response in the clinically important opportunistic pathogen Pseudomonas aeruginosa. Phage-infected P. aeruginosa subpopulations are isolated from uninfected subpopulations by the production of a stress-induced signal. Activation of the stress...
Research ArticleEntry Exclusion of Conjugative Plasmids of the IncA, IncC, and Related Untyped Incompatibility GroupsIncA and IncC conjugative plasmids drive antibiotic resistance dissemination among several pathogenic species of Gammaproteobacteria due to the diversity of drug resistance genes that they carry and their ability to mobilize antibiotic resistance-conferring genomic islands such as SGI1 of Salmonella enterica. While historically grouped as “IncA/C,” IncA and...
- Research Article | SpotlightDeciphering the Function of New Gonococcal Vaccine Antigens Using Phenotypic Microarrays