cell cycle
Research ArticleClpX Is Essential and Activated by Single-Strand DNA Binding Protein in MycobacteriaTuberculosis, caused by Mycobacterium tuberculosis, imposes a major global health burden, surpassing HIV and malaria in annual deaths. The ClpP1P2 proteolytic complex and its cofactor ClpX are attractive drug targets, but their precise cellular functions are unclear.
Research ArticleRegulation of Bacterial Cell Cycle Progression by Redundant PhosphatasesTwo-component signal transduction systems are widely used by bacteria to adequately respond to environmental changes by adjusting cellular parameters, including the cell cycle. In Caulobacter crescentus, PleC acts as a phosphatase that indirectly protects the response regulator CtrA from premature inactivation during the G1 phase of the cell cycle. Here, we...
Research Article | SpotlightProgrammed Proteolysis of Chemotaxis Proteins in Sinorhizobium meliloti: Features in the C-Terminal Region Control McpU DegradationThe symbiotic bacterium Sinorhizobium meliloti contributes greatly to growth of the agriculturally valuable host plant alfalfa by fixing atmospheric nitrogen. Chemotaxis of S. meliloti cells toward alfalfa roots mediates this symbiosis. The present study establishes programmed proteolysis as a...
MinireviewRegulation of Cell Division in Bacteria by Monitoring Genome Integrity and DNA Replication StatusAll organisms regulate cell cycle progression by coordinating cell division with DNA replication status. In eukaryotes, DNA damage or problems with replication fork progression induce the DNA damage response (DDR), causing cyclin-dependent kinases to remain active, preventing further cell cycle progression until replication and repair are complete.
- Microbial Cell BiologyChanges in the Min Oscillation Pattern before and after Cell Birth
- Microbial Cell BiologyDynamics of Two Phosphorelays Controlling Cell Cycle Progression in Caulobacter crescentus