chaperone
Research Article | SpotlightPhage Proteins Required for Tail Fiber Assembly Also Bind Specifically to the Surface of Host Bacterial StrainsWith the growing interest in using phages to combat antibiotic-resistant infections or manipulate the human microbiome, establishing approaches for the modification of phage host range has become an important research topic. Tfa proteins are a large family of proteins known previously to function as chaperones for the folding of phage fibers, which are crucial determinants of host range for long-tailed phages. Here, we reveal that some...
Research ArticleDependency of Coxiella burnetii Type 4B Secretion on the Chaperone IcmSThe intracellular pathogen Coxiella burnetii employs a type 4B secretion system (T4BSS) that promotes growth by translocating effectors of eukaryotic pathways into host cells. T4BSS regulation modeled in Legionella pneumophila indicates IcmS facilitates effector translocation. Here, we characterized...