hydrogen peroxide
Research ArticleRegulatory Involvement of the PerR and SloR Metalloregulators in the Streptococcus mutans Oxidative Stress ResponseIn 2020, untreated dental caries, especially in the permanent dentition, ranked among the most prevalent infectious diseases worldwide, disproportionately impacting individuals of low socioeconomic status. Untreated caries can lead to systemic health problems and have been associated with extended school and work absences, inappropriate use of emergency departments, and an inability for military forces to deploy.
Research Article | SpotlightInteraction between Streptococcus pneumoniae and Staphylococcus aureus Generates ·OH Radicals That Rapidly Kill Staphylococcus aureus StrainsStreptococcus pneumoniae strains produce hydrogen peroxide (H2O2) to kill bacteria in the upper airways, including pathogenic Staphylococcus aureus strains. The targets of S. pneumoniae-produced H2...
Research ArticleGlutathione Synthesis Contributes to Virulence of Streptococcus agalactiae in a Murine Model of SepsisApproximately 10 to 30% of women are naturally and asymptomatically colonized by Streptococcus agalactiae. However, transmission of S. agalactiae from mother to newborn during vaginal birth is a leading cause of neonatal meningitis. Although colonized mothers who are at risk for transmission to the...
Research ArticleTranscriptional Regulation Contributes to Prioritized Detoxification of Hydrogen Peroxide over Nitric OxideBacteria can be exposed to H2O2 and NO· concurrently within phagosomes. In such multistress situations, bacteria could have evolved to simultaneously degrade both toxic metabolites or preferentially detoxify one over the other. Here, we found that simultaneous exposure to H2O2 and NO· leads to prioritized detoxification, where detoxification of NO· is hampered until H2O2...
- MOLECULAR BIOLOGY OF PATHOGENSThiol Peroxidase Protects Salmonella enterica from Hydrogen Peroxide Stress In Vitro and Facilitates Intracellular Growth