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Lyme disease

  • Open Access
    DksA Controls the Response of the Lyme Disease Spirochete <em>Borrelia burgdorferi</em> to Starvation
    Research Article
    DksA Controls the Response of the Lyme Disease Spirochete Borrelia burgdorferi to Starvation

    The Lyme disease bacterium Borrelia burgdorferi survives diverse environmental challenges as it cycles between its tick vectors and various vertebrate hosts. B. burgdorferi must withstand prolonged periods of starvation while it resides in unfed...

    William K. Boyle, Ashley M. Groshong, Dan Drecktrah, Julie A. Boylan, Frank C. Gherardini, Jon S. Blevins, D. Scott Samuels, Travis J. Bourret
  • DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span>
    Research Article
    DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi

    Lyme disease is the most prevalent vector-borne disease in North America and is classified by the Centers for Disease Control and Prevention (CDC) as an emerging infectious disease with an expanding geographical area of occurrence. Previous studies have shown that the causative bacterium, Borrelia burgdorferi, methylates its genome using restriction modification...

    Timothy Casselli, Yvonne Tourand, Adam Scheidegger, William K. Arnold, Anna Proulx, Brian Stevenson, Catherine A. Brissette
  • Positive and Negative Regulation of Glycerol Utilization by the c-di-GMP Binding Protein PlzA in <span class="named-content genus-species" id="named-content-1">Borrelia burgdorferi</span>
    Research Article
    Positive and Negative Regulation of Glycerol Utilization by the c-di-GMP Binding Protein PlzA in Borrelia burgdorferi

    The Lyme disease pathogen, Borrelia burgdorferi, has a simple cyclic dimeric GMP (c-di-GMP) signaling system essential for adaptation of the pathogen to the complicated tick environment. The c-di-GMP effector of B. burgdorferi, PlzA, has been shown to regulate multiple cellular processes, including...

    Jun-Jie Zhang, Tong Chen, Youyun Yang, Jimei Du, Hongxia Li, Bryan Troxell, Ming He, Sebastian E. Carrasco, Mark Gomelsky, X. Frank Yang
  • MOLECULAR BIOLOGY OF PATHOGENS
    GuaA and GuaB Are Essential for Borrelia burgdorferi Survival in the Tick-Mouse Infection Cycle
    Mollie W. Jewett, Kevin A. Lawrence, Aaron Bestor, Rebecca Byram, Frank Gherardini, Patricia A. Rosa
  • Microbial Cell Biology
    The Flat-Ribbon Configuration of the Periplasmic Flagella of Borrelia burgdorferi and Its Relationship to Motility and Morphology
    Nyles W. Charon, Stuart F. Goldstein, Michael Marko, Chyongere Hsieh, Linda L. Gebhardt, M. Abdul Motaleb, Charles W. Wolgemuth, Ronald J. Limberger, Nancy Rowe
  • Genomics and Proteomics
    Comparative Genome Hybridization Reveals Substantial Variation among Clinical Isolates of Borrelia burgdorferi Sensu Stricto with Different Pathogenic Properties
    Darya Terekhova, Radha Iyer, Gary P. Wormser, Ira Schwartz
  • MOLECULAR BIOLOGY OF PATHOGENS
    Transcriptional Regulation of the Borrelia burgdorferi Antigenically Variable VlsE Surface Protein
    Tomasz Bykowski, Kelly Babb, Kate von Lackum, Sean P. Riley, Steven J. Norris, Brian Stevenson
  • GENETICS AND MOLECULAR BIOLOGY
    Role of Borrelia burgdorferi Linear Plasmid 25 in Infection of Ixodes scapularis Ticks
    Keith O. Strother, Aravinda de Silva
  • MOLECULAR BIOLOGY OF PATHOGENS
    bdrF2 of Lyme Disease Spirochetes Is Coexpressed with a Series of Cytoplasmic Proteins and Is Produced Specifically during Early Infection
    Hongming Zhang, Abayami Raji, Michael Theisen, Paul R. Hansen, Richard T. Marconi
  • MOLECULAR BIOLOGY OF PATHOGENS
    The Etiological Agent of Lyme Disease, Borrelia burgdorferi, Appears To Contain Only a Few Small RNA Molecules
    Yngve Östberg, Ignas Bunikis, Sven Bergström, Jörgen Johansson

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