molecular genetics

  • Holin-Dependent Secretion of the Large Clostridial Toxin TpeL by <span class="named-content genus-species" id="named-content-1">Clostridium perfringens</span>
    Research Article
    Holin-Dependent Secretion of the Large Clostridial Toxin TpeL by Clostridium perfringens

    Little is known about the mechanism by which LCTs are secreted. Since LCTs are major virulence factors in clostridial pathogens, we wanted to define the mechanism by which an LCT in C. perfringens, TpeL, is secreted by a protein (TpeE) lacking homology to previously described secretion-associated holins.

    Angela Saadat, Stephen B. Melville
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