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phage

  • Phage Proteins Required for Tail Fiber Assembly Also Bind Specifically to the Surface of Host Bacterial Strains
    Research Article | Spotlight
    Phage Proteins Required for Tail Fiber Assembly Also Bind Specifically to the Surface of Host Bacterial Strains

    With the growing interest in using phages to combat antibiotic-resistant infections or manipulate the human microbiome, establishing approaches for the modification of phage host range has become an important research topic. Tfa proteins are a large family of proteins known previously to function as chaperones for the folding of phage fibers, which are crucial determinants of host range for long-tailed phages. Here, we reveal that some...

    Olesia I. North, Alan R. Davidson
  • Open Access
    Nanoluciferase Reporter Mycobacteriophage for Sensitive and Rapid Detection of <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Drug Susceptibility
    Research Article
    Nanoluciferase Reporter Mycobacteriophage for Sensitive and Rapid Detection of Mycobacterium tuberculosis Drug Susceptibility

    Mycobacterium tuberculosis, the causative agent of tuberculosis disease, remains a public health crisis on a global scale, and development of new interventions and identification of drug resistance are pillars in the World Health Organization End TB Strategy. Leveraging the tractability of the TM4 mycobacteriophage and the sensitivity of the nanoluciferase reporter...

    Paras Jain, Spencer Garing, Deepshikha Verma, Rajagopalan Saranathan, Nicholas Clute-Reinig, Jacob Gadwa, Chelsea Peterson, Gleda Hermansky, Anna Astashkina Fernandez, Emmanuel Asare, Torin R. Weisbrod, Ethan Spencer, Claire V. Mulholland, Michael Berney, David Bell, Kevin P. Nichols, Anne-Laure M. Le Ny, Diane Ordway, William R. Jacobs, Akos Somoskovi, Kyle J. Minch
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