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spirochetes

  • Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in <em>Treponema denticola</em>
    Research Article
    Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in Treponema denticola

    Treponema denticola is one of numerous host-associated spirochetes, a group including commensals, pathobionts, and at least one frank pathogen. While most T. denticola research concerns its role in periodontitis, its relative tractability for growth and genetic manipulation make it a useful model...

    Prakaimuk Saraithong, M. Paula Goetting-Minesky, Peter M. Durbin, Spencer W. Olson, Frank C. Gherardini, J. Christopher Fenno
  • Immunotopological Analysis of the <em>Treponema denticola</em> Major Surface Protein (Msp)
    Research Article
    Immunotopological Analysis of the Treponema denticola Major Surface Protein (Msp)

    Treponema denticola is among a small subset of the oral microbiota contributing to severe periodontal disease. Due to its relative genetic tractability, T. denticola is a model organism for studying Treponema physiology and host-microbe interactions. T. denticola Msp is a highly expressed outer membrane-associated oligomeric protein that binds fibronectin, has cytotoxic pore-forming activity, and...

    Valentina Godovikova, M. Paula Goetting-Minesky, John C. Timm, J. Christopher Fenno
  • Research Article
    RNase III Processing of rRNA in the Lyme Disease Spirochete Borrelia burgdorferi
    Melissa L. Anacker, Dan Drecktrah, Richard D. LeCoultre, Meghan Lybecker, D. Scott Samuels
  • Research Article
    Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial Surface
    Alexander S. Dowdell, Maxwell D. Murphy, Christina Azodi, Selene K. Swanson, Laurence Florens, Shiyong Chen, Wolfram R. Zückert
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