virus
- Research ArticleCas4 Nucleases Can Effect Specific Integration of CRISPR Spacers
The Cas4 family endonuclease is an essential component of the adaptation module in many variants of CRISPR-Cas adaptive immunity systems. The Crenarchaeota Sulfolobus islandicus REY15A carries two cas4 genes (cas4 and csa1) linked to the CRISPR arrays. Here, we demonstrate that Cas4 and Csa1 are essential to CRISPR spacer...
- Research ArticleBacteriophages of the Urinary Microbiome